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Mesothelioma Metastasis

Mesothelioma metastasis refers to the spread of mesothelioma cancer from its point-of-origin to other areas of the body. Linked exclusively with asbestos exposure, malignant mesothelioma is an aggressive type of cancer that has thus far proven incurable.

Unlike other tumor types, mesothelioma is by nature malignant. Malignant tumors are characterized by their progressive and uncontrolled growth patterns. Malignancy and metastasis are interconnected because of the fact that malignancy yields metastasis. The uncontrolled growth patterns of malignant tumors have a tendency to give way to the spread of cancer cells throughout the body.

Mesothelioma metastasis occurs when mesothelioma cancer cells break off from the primary tumor and invade surrounding tissues. Oftentimes, mesothelioma cancer cells enter the blood stream and/or the lymphatics, where they are shuttled throughout the body.

Mesothelioma metastasis can lead to the development of additional tumors, commonly referred to as secondary cancer or metastatic cancer. A case of pleural mesothelioma can metastasize and spread to the lungs, forming a secondary cancer of the lungs. The cancer cells of the secondary tumor would be similar to those of the primary cancer; namely pleural mesothelioma cells. A biopsy of cancerous tissue of the lung could yield the discovery of cancer cells resembling pleural mesothelioma cells. Histopathologists could therefore diagnose the cancer of the lung as a secondary cancer and trace metastasis back to the point-of-origin; pleural mesothelioma.

 

Mesothelioma Metastasis and Angiogenesis

Metastasis revolves around the uncontrolled division and replication of cancer cells. In order for division and replication of cancer cells to occur, a tumor requires a continuous flow of oxygen and essential nutrients via blood vessels. A newly formed tumor signals nearby blood vessels by secreting Vascular Endothelial Growth Factors (VEGF), inducing blood vessel growth into the tumor through which the delivery of oxygen and essential nutrients can occur.

VEGF is a family of naturally occurring proteins that stimulate the growth and survival of the cells of the vascular system, the network of blood vessels (arteries arterioles, venules, capillaries and veins) in the body. VEGF is found in very high levels in most malignant mesothelioma patients, allowing for the rapid metastasis of the tumor.

The formation of new blood vessels in the body is called angiogenesis. Although angiogenesis is a natural process essential to wound healing, it also feeds the growth and metastasis of cancerous tumors. Angiogenesis inhibitors prevent the continuous formation of new blood vessels by halting production of VEGF. Angiogenesis inhibitors can either occur naturally or be produced synthetically (anti-angiogenesis drugs).

 

Mesothelioma Treatment and Anti-Angiogenesis Drugs

Mesothelioma treatments have thus far been unable to slow the progression of the aggressive asbestos disease. As such, most mesothelioma research has been devoted to the development of new mesothelioma treatment modalities and chemotherapy drugs. One of the more promising mesothelioma treatment developments revolves around a new line of chemotherapy agents called anti-angiogenesis drugs.

For the most part, anti-angiogenesis drugs remain in the clinical trial process through which they are being tested for safety and effectiveness. Anti-angiogenesis drugs that have been used in animal studies have been successful in shrinking and killing cancerous cells. Although anti-angiogenesis drugs have yet to prove as successful in human studies, many medical professionals expect them to yield similar results.

Two anti-angiogenesis drugs currently receiving a great deal of attention are Veglin and Avastin. Veglin is designed to target a wide range of cancers, including malignant mesothelioma and renal cell carcinoma, while Avastin is designed primarily to target cancers of the colon and rectum. Results from the first two phases of Veglin clinical trials have left researchers feeling confident that the drug could have significant values in the future treatments for mesothelioma.

Stages of Malignant Mesothelioma
KNOW. Mesothelioma

Types of - Mesothelioma Types

The most common type of mesothelioma is the pleural mesothelioma. The pleura are thin membranes found between the lungs and the chest cavity. They provide a lubricated surface so that the lungs do not chafe against the chest walls. Thus, a pleural mesothelioma is often referred to as a "lung" cancer.

Another form of mesothelioma is the peritoneal mesothelioma. The peritoneum is the membrane that encloses the organs of the abdomen. While peritoneal mesotheliomas are less common than pleural mesotheliomas, they tend to be more invasive, and thus result in a shorter life expectancy for the patient. Mesotheliomas have also been found in the stomach, heart (pericardial mesothelioma), and other abdominal organs.



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What is Pleural Mesothelioma?

Pleural mesothelioma, pleura mesothelioma, or malignant pleural mesothelioma is mesothelioma cancer in the lining of the lungs. This is different from lung cancer, which refers to any type of malignant tumor that originates in the lungs.

The pleura, is the tissue lining or covering that surrounds the lungs. There are two pleura. These can be called pleural membranes. The gap between them is called the pleural space. The pleura are fibrous sheets. They help to protect the lungs. They produce a lubricating fluid that fills the gap between the two pleura. This helps the lungs to move smoothly in the chest when they are inflating and deflating as we breathe.

The first step in detecting pleural mesothelioma is, typically, a chest x-ray or CT scan. This is often followed by a bronchoscopy, using a viewing.

Sope to look inside the lungs. 

A family ravaged by asbestos

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WASHINGTON, D.C. -- The four Bertrand brothers were a tightly knit bunch, following their father into the insulation trade in the 1950s. They kicked up dust all day as they labored to wrap huge boilers and miles of pipelines with blocks of asbestos and a mudlike asbestos finishing coat.

Sawing and mixing left their faces and hands coated with white film. Like thousands of insulators across the country, the Bertrands didn't know that the white dust could kill.

Bob Bertrand, 64, a St. Paul father of four, is the only surviving brother of a family ravaged by asbestos. And he is fighting for his life against mesothelioma, a rare cancer of the lining of the lungs almost always caused by exposure to asbestos fibers.

He said asbestos contributed to the deaths of two of his brothers, and he and his family suspect it was a factor in the death of his father and his third brother.

Surviving family members are convinced that mesothelioma, which causes fluid to build in the body, killed family patriarch Louis Bertrand. He died in 1967 at age 68 of a burst stomach.

The oldest son, Louis Francis Bertrand, was next, dying in 1970 at age 42 of a heart attack. There was never an asbestos-related diagnosis, but he had had problems breathing, and there had been no family history of heart disease. Seven years later, 20-year-old Louis Jr. stepped into the family's back yard and shot himself to death.

"He wanted to be with his dad," Bob Bertrand said, choking back tears.

In 1985, 51-year-old Eugene Bertrand, who suffered from asbestosis, died of a heart attack. Asbestosis is known to contribute to heart attacks by limiting the flow of oxygen to the heart. Then in 1993, mesothelioma took the life of Raymond Bertrand, age 57.

Bob Bertrand's sister, Alice, married an insulator, Jim Garfield, who died of mesothelioma at age 63 in 1992. Garfield's brother, Mark, also an insulator, died in 1998 of asbestos-related disease, Alice Garfield said.

Alice Garfield, 72, of White Bear Lake, and Bob Bertrand's wife, Jacqueline, 61, have been diagnosed with asbestosis -- apparently from shaking dust off their husbands' clothes.

"It's unreal . . . just unreal," Bertrand said of asbestos' toll on his family. "I can't even put it into words."

Firsthand

The Bertrands are among a long line of insulators whose lives turned tragic because of the asbestos disaster. No union has been harder hit than the International Association of Heat and Frost Insulators and Asbestos Workers.

"Nobody knows the hideous devastation that's been caused by asbestos better than the asbestos workers," said Terry Lynch, the political and legislative director for the 30,000-member union. "We know it firsthand."

Grogan said mesothelioma victims typically "suffer from six to 13 months," often from fierce pain as tumors press against nerve endings along their rib cages.

"The guys that die from pure asbestosis choke themselves to death for three and four years," he said. "They cough a minimum of 20 hours a day. I don't think they get two hours sleep."

Huffing and puffing

Bob Bertrand, who spent 45 years as an insulator, said it wouldn't surprise him if insurers knew of asbestos' threats, noting that manufacturers "kept on pushing" the products after learning of the dangers.

When he learned he had mesothelioma on Oct. 4, 2001, he said, a doctor told him: "You've got four to six months and you're dead."

His children scrambled to research the disease, he said, but "every time they'd come up with something, it'd make you sadder, knowing that these companies knew that the stuff was dangerous."

Despite his fast-moving cancer, he went back to work, huffing and puffing through the year's end, before retiring.

With his condition inoperable because the cancer had spread to both lungs, Bertrand recently went to see Dr. Arkadiusz Dudek, a University of Minnesota oncologist experimenting with a chemotherapy approach for late-term mesothelioma patients.

The treatments sapped Bertrand's strength but shrank the tumors by 25 percent -- enough to ease his pain and keep him alive.

Bertrand said he has moved beyond anger to acceptance of his plight.

"I got the extra time to work out everything with my family."




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